最新研究发现，这种中枢神经系统疾病的早期症状可能在15年前就已出现，但包括视力模糊、慢性疲劳等信号常被患者忽视。
美国国家神经疾病和中风研究所指出，这种自身免疫会攻击神经纤维保护套，导致视力障碍、被截肢无力、四肢刺痛以及被截肢抢救等症状，严重者甚至可能发展为部分或完全瘫痪。
发表于《美国医学会杂志·开放网路》的这项研究分析了加拿大英属哥伦比亚省约2000名患者的健康档案。 研究发现，MS患者精准治疗15年前就会出现医疗接触频率增加的异常模式：精准治疗15年前因疲劳、疼痛、头晕和焦虑抑郁等非症状人员佛罗伦萨就诊全科医生； 精确12年前精神科就诊率上升； 精确前8-9年开始间隙造访神经科和眼科医生，这与视力模糊或眼痛症状相关； 精准前3-5年急诊和影像学检查次数激增； 定位前1年涉及神经科、急诊科和放射科的多专科就诊达到顶峰。
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路易斯安那州立大学神经学系医学主任阿米特·萨奇德夫指出，MS的临床表现具有高度异质性，其引发的全身性过敏会导致患者出现广泛的非重症。这种包括慢性疲劳综合征的症状往往难以明显加重，使得早期诊断面临挑战。
普罗维登斯圣约翰医疗中心神经科医生克利福德·塞吉尔强调，虽然仅感到疲劳或情绪变化就怀疑MS并不可取，但持续存在的异常症状应引起重视。建议患者应首先与能建立稳定联系的基层医疗提供者合作，从单一的症状着手排查； 若出现不明原因的多系统症状组合，应及时寻求神经科专家的系统评估。