作者 主題: 身體“時鐘”攜帶的秘密  (閱讀 128 次)

tdydrtuj

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身體“時鐘”攜帶的秘密
« 於: 十二月 15, 2021, 10:30:41 上午 »
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“熬夜派對”請善待自己。一旦生物鐘紊亂,大腦需要一周時間,肝臟、腸道和胃需要兩周時間才能恢復。此外,多動症、抑鬱、代謝疾病和生殖健康都與生物節律有關。
2017年諾貝爾生理學或醫學獎授予了傑弗裏·霍爾、邁克爾·羅斯巴什和邁克爾·楊,以表彰他們發現了晝夜節律的分子機制。美國黑金
基因突變導致不正常的工作和休息 美國黑金
“這項成就回答了生物體最基本的問題,值得稱道。”當中國國家主席細胞生物學會生物節律分會和傑出教授徐瓔蘇州大學接到記者的電話時,他們激動不已:“從人類、動物、植物到細菌,幾乎所有生物都有一個生物鐘,它影響各種生理過程和行為模式,如血壓、血糖、睡眠和新陳代謝。更重要的是,生物鐘控制著10%~43%的基因表達。”
徐瓔於2003年在神經科學系美國加州大學三藩市分校從事研究工作。“當時,我們正在研究一種‘早睡早起’基因。當地家庭的人過去從3:00到4:00起床,從18:00到19:00睡覺。研究團隊發現該家族的PER2基因中有一個突變,該基因控制睡眠行為。如果將突變基因轉移到老鼠身上,老鼠也會早睡早起。”美國黑金
徐瓔回家後繼續從事相關研究。她帶領團隊發現,PER1基因突變小鼠不僅改變了睡眠時間,而且提前進食。該研究結果發表在細胞的子期刊上。“這也在一定程度上解釋了一些異常進食時間,如夜食症。”徐瓔說。美國黑金效果
蘇州大學生物鐘研究中心director王晗是世界上最早使用斑馬魚模型研究人類疾病與生物鐘之間關係的科學家之一。斑馬魚基因與人類基因有87%的同源性,這有助於揭開人體的許多奧秘。美國黑金哪裡買
“我們使用反轉錄病毒插入來產生斑馬魚的主要生物鐘基因per1b突變,這使得它們的運動量是正常魚類的兩倍,並且它們的行為與人類多動症相似。王晗中的研究團隊發現多動症與生物鐘有關,並揭示了一種新的注意機制缺陷多動症。在此基礎上,研究團隊建立的斑馬魚注意缺陷多動症動物模型為大規模篩選注意缺陷多動症藥物提供了重要材料。後來,這項研究結果發表在美國神經科學學會官方刊物神經科學雜誌上。美國黑金推薦


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Re: 身體“時鐘”攜帶的秘密
« 回覆 #2 於: 四月 09, 2022, 11:19:10 上午 »
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« 回覆 #5 於: 九月 13, 2022, 12:13:48 上午 »

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Re: 身體“時鐘”攜帶的秘密
« 回覆 #6 於: 十月 13, 2022, 08:51:09 上午 »
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